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It kicks off at 20:45 CET (19:45 GMT) at the Stadio Olimpico in Rome.
It’s the last game of the Serie A round 28.
The Bianconcelesti are still without their best scorer, Valentin Castellanos, but have a big chance to leapfrog Juventus in fourth place after the Bianconeri’s 4-0 home loss to Atalanta on Sunday night.
The home side must cope without Luca Pellegrini, Elseid Hysaj, Valentin Castellanos and Nuno Tavares.
Isaak Touré and Razvan Sava are unavailable for the visitors.
Udinese are unbeaten in the last five matches, collecting four wins and just one draw.
Lazio beat Viktoria Plzen 2-1 in the first leg of the Europa League Round of 16 last week and will host the Czech side in the return leg this coming Thursday.
Football Italia will be following the game and the build-up live on the LIVEBLOG.
